منابع مشابه
Enhancer elements
Defining transcriptional regulatory signals represents an essential step toward our understanding of eucaryotic gene expression. Analysis of genes transcribed by polymerase II has revealed a complex and interrelated set of “promoter elements.” Enhancers or activators are among the set of eucaryotic promoter elements that appear to increase transcriptional efficiency in a manner relatively indep...
متن کاملGenome-wide identification of enhancer elements.
We present a prospective genome-wide regulatory element database for the sea urchin embryo and the modified chromosome capture-related methodology used to create it. The method we developed is termed GRIP-seq for genome-wide regulatory element immunoprecipitation and combines features of chromosome conformation capture, chromatin immunoprecipitation, and paired-end next-generation sequencing wi...
متن کاملThe chromatin fingerprint of gene enhancer elements.
Different cell types within a single organism are generally distinguished by strikingly different patterns of gene expression, which are dynamic throughout development and adult life. Distal enhancer elements are key drivers of spatiotemporal specificity in gene regulation. Often located tens of kilobases from their target promoters and functioning in an orientation-independent manner, the iden...
متن کاملDiscrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators.
In Drosophila, genes of the Enhancer of split Complex [E(spl)-C] are important components of the Notch (N) cell-cell signaling pathway, which is utilized in imaginal discs to effect a series of cell fate decisions during adult peripheral nervous system development. Seven genes in the complex encode basic helix-loop-helix (bHLH) transcriptional repressors, while 4 others encode members of the Be...
متن کاملEnhancer Chip: Detecting Human Copy Number Variations in Regulatory Elements
Critical functional properties are embedded in the non-coding portion of the human genome. Recent successful studies have shown that variations in distant-acting gene enhancer sequences can contribute to disease. In fact, various disorders, such as thalassaemias, preaxial polydactyly or susceptibility to Hirschsprung's disease, may be the result of rearrangements of enhancer elements. We have a...
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ژورنال
عنوان ژورنال: Cell
سال: 1983
ISSN: 0092-8674
DOI: 10.1016/0092-8674(83)90410-5